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Arava affects the immune system and decreases inflammation. Arava is used to reduce the signs and symptoms of rheumatoid arthritis, reduce damage to the joints caused by rheumatoid arthritis, and to improve physical function in people with rheumatoid arthritis.

Take Arava exactly as directed on the package or as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. It can be taken with or without. Never take more of this medication than is prescribed for you.

This drug may cause following serious side effects : an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue, or face, or hives), changes in liver function (may be detected by blood tests or cause symptoms such as yellowing of the skin or eyes, pale colored stools or dark colored urine, unusual fatigue, or abdominal pain), decreased bone marrow function or blood problems (may be detected by blood tests or cause symptoms such as extreme or unusual fatigue, easy bruising or bleeding, black, bloody or tarry stools, fever or chills, or signs of infection such as fever, chills, or sore throat), or skin rash, or sores in the mouth. Other, less serious side effects may be more likely to occur. Continue to take Arava and talk to your doctor if you experience headache, increased blood pressure, muscle aches, nausea, diarrhea, or hair loss.

Tell your doctor your medical history especially : If you have liver disease or a history of hepatitis, a history of significant alcohol use, kidney disease, an immune system disease, recently received a live vaccine, poor bone marrow function, or a current or chronic infection. Arava should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Consult your doctor before breast-feeding. Discuss with your doctor the use of alcohol while taking Arava. Alcohol and Arava can both be damaging to the liver. Arava can lower the activity of the immune system making you more susceptible to infection. Avoid contact with people who have colds, the flu, or other contagious illnesses. In addition, do not receive vaccines that contain a live strain of the virus (e.g., live oral polio vaccine) and avoid contact with individuals who have recently been vaccinated with a live virus.

Tell your doctor of all nonprescription and prescription medication you may use, especially : Cholestyramine (Questran, Prevalite, LoCHOLEST), methotrexate (Rheumatrex), or rifampin (Rifadin, Rimactane). Drugs other than those listed here may also interact with Arava.

Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of an allopurinol overdose may include diarrhea, abdominal pain, blood problems, and liver problems.

Do not share Arava with others.

If you miss an Arava dosage, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Store Arava at room temperature between 68 and 77 degrees F (20-25 degrees C) away from sunlight and moisture.

The following Informationrmation is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.